Medical preparation "Liniment synthomycin"
Problem skin is constantly in need of special care with the use of cosmetic and therapeutic agents. One of the most effective and at the same time affordable and easy-to-use preparations for acne is Liniment Sintomycin ointment. Its active ingredient is chloramphenicol antibiotic. It is a powerful bacteriostatic antimicrobial substance. It is well proven in the treatment of acne, various rashes, especially bacterial etiology. There are varieties of ointment with different concentrations of the active substance: 1, 5 and 10%. In addition, the drug contains auxiliary components: distilled water, castor oil, emulsifier. Shades of ointment range from yellowish to milky white.
Few people know that "chloramphenicol" and "syntomycin" are just different names for the same substance - the antibiotic "levomycetin." He is known for being the first antibiotic drug that was synthesized in the laboratory.This antibiotic kills bacteria or significantly slows down the rate of their growth and, therefore, reproduction, suppressing their normal protein synthesis. Both gram-positive and gram-negative microorganisms are sensitive to it. They also include staphylococci with streptococci, which most often provoke acne, rashes, and boils. Therefore, Liniment Syntomycin ointment destroys even strains of pathogens that are resistant to tetracycline and penicillin medications, as well as sulfanilamides. This makes it so effective (assuming systematic use).
The principle of operation and effectiveness
The tool "Liniment synthomycin" has a wide range of antibacterial activity. Castor oil, which is included in its composition, has a softening effect on the skin, helps to soften the cork acne or comedones, and chloramphenicol suppresses bacteria that cause inflammation of the sebaceous glands. The drug is very effective, but you should not expect a lightning-fast result. Acne therapy is, first and foremost, a system.Ointment will help to get rid of them for a long time and to make a clean face, if you follow the recommendations and adhere to the course of treatment.
As already mentioned, the active ingredient of the drug is chloramphenicol - a broad-spectrum antibiotic. It has a high level of antibacterial activity against pathogens of wound infections and various types of purulent-inflammatory processes. Chloramphenicol has a high level of lipophilicity. It easily penetrates the cell membranes of microorganisms and binds (reversibly) to the subunits of the 50S ribosome of bacteria. This leads to a delay in the movement of amino acids important for the life of the microorganism to the peptide chains under construction. The result is a violation of the alignment of peptide bonds, as well as protein synthesis. The medical preparation promotes healing and cleansing of trophic ulcers, burn-type wounds, and also accelerates tissue regeneration.
Indications for use
It is advisable to establish the level of sensitivity of the patient’s microflora, which causes the ailment, to the medication before starting therapy.Liniment synthomycin is used to treat the following diseases:
- pustular lesions of the skin;
- furunculosis (purulent multiple inflammation);
- purulent wounds;
- carbunculosis (acute diffuse purulent-necrotic inflammation of a number of hair follicles and sebaceous glands, located close to each other);
- long-term non-healing ulcers;
- nipple cracks in nursing mothers and parturients;
- burns (2nd and 3rd degree);
- purulent inflammation of the mucous membranes;
The drug is well suited for the treatment of pulmonary infections of the skin of bacterial etiology triggered by pathogens sensitive to the antibiotic. For more serious and deep lesions of the skin of an infectious nature, it should be used together with the appropriate systemic antibacterial drugs Liniment syntomycin. The instruction states that for such serious diseases, internal means should be combined with external ones.
Dosage and administration
Medication is applied exclusively outwardly. After surgical manipulations, liniment synthomycin should be applied directly to the surface of wounds and burns.After that, a sterile dressing is placed on top of them (you can also use compressive and parchment material), which must be changed daily. Medication can also be applied to the dressing itself, and then to the wound. Processed liniment swabs fill the cavity of purulent abscesses after surgical treatment. In fistulous passages, you can enter gauze turunda with a medical preparation. For acne therapy, as a rule, use a direct application of funds on a pimple. You can also apply a bandage (change daily). "Linment synthomycin" is also applied to a tampon, which is attached with a patch to a pimple or other problem area. Before starting treatment, the face should be thoroughly cleaned of cosmetics. The ointment is absorbed very quickly. When treating long-term non-healing burns and wounds, it is desirable to use liniment 5 or 10%.
Use during pregnancy and lactation
Chloramphenicol penetrates well through the placenta. But the studies did not reveal any adverse effect of this antibiotic on the fetus during external use. Whether the medication penetrates into breast milk is not known for certain.But no complications were recorded. Therefore, treatment of nipple cracks in nursing mothers with Liniment Syntomycin does not imply cessation of feeding. This is one of its advantages. The drug is preferably used after the feeding process. Breast should be carefully washed and apply ointment (5%) on it on a sterile napkin. Before feeding, the remnants of the medication should be removed from the nipple and the surrounding skin with a clean swab. After that, the chest should be gently rinsed.
The drug is contraindicated in case of individual intolerance; oppression of bone marrow hematopoiesis; allergies and toxic reactions; acute intermittent porphyria; glucose-6-phosphate dehydrogenase deficiency; hepatic, renal failure; fungal lesions of the epidermis; psoriasis; eczema; in the first month after birth. The lack of osmotic activity makes it undesirable to use the drug during the first phase of the wound process (edema, profuse suppuration, the presence of tissue necrosis, severe pain).
Side Effects of Medication
The use of Liniment synthomycin ointment can provoke allergic reactions: skin rashes, angioedema.In extremely rare cases of the hematopoietic system are observed: leukopenia, thrombocytopenia, reticulocytopenia, erythropenia, granulocytopenia, agranulocytosis, aplastic anemia.
Interaction with other drugs
Simultaneous use with lincomycin, clindamycin or erythromycin can mutually weaken the activity of drugs. The drug "Liniment synthomycin" reduces the antibacterial effect of antibiotics of the penicillin and cephalosporin groups.